Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases
Bone is a dynamic tissue that must respond to developmental, repair, and remodeling cues in a rapid manner with changes in gene expression.Carefully-coordinated cycles of bone resorption and formation are essential for healthy skeletal growth and maintenance.Osteoclasts are large, multinucleated cells that are responsible for breaking down bone by